BIOTECHNOLOGY INDUSTRIAL
INTERNSHIPS
To ensure that trainees experience the process and the problems associated with
the development of biotechnology products, each trainee is required to complete
an internship in a pharmaceutical or biotechnology company. Trainees are
expected to fulfill this internship requirement any time after their 2nd year
as a graduate student at The University of Kansas. The site for the
trainee's internship and the duration of the internship will be decided in
consultation with the trainer and the Steering Committee.
Potential industrial internship sites include Abbott Laboratories, Abbott
Park, IL; Alkermes, Inc., Cambridge, MA; Alza Corp., Palo Alto, CA; Amgen,
Thousand Oaks, CA; Aradigm, San Francisco, CA; Boehringer-Ingelheim,
Ridgefield, CT; Bristol-Myers Squibb, New Brunswick, NJ; DuPont Merck
Pharmaceutical Co., Wilmington, DE; Gene Medicine, Woodland, TX; Genentech,
Inc., South San Francisco, CA; Gilead Sciences, Foster City, CA; Glaxo
Wellcome, Research Triangle Park, NC; Hoechst Marion Roussel, Kansas City, MO;
Hoffmann-LaRoche, Inc., Nutley, NJ; Inhale, Palo Alto, CA; R.W. Johnson Pharm.
Res. Inst., Spring House, PA; Lilly Research Laboratories, Indianapolis, IN;
MegabiosCorp., Burlingame, CA; Merck Sharp & Dohme Research Laboratories,
West Point, PA; Parke-Davis Pharmaceutical Research, Ann Arbor, MI; Pharmacia
& Upjohn, Kalamazoo, MI: The Procter & Gamble Co., Cincinnati, OH;
RhonePoulenc Rorer, Collegeville, PA; Scios Nova, Inc., Mountain View, CA;
Searle, Skokie, IL; SmithKline Beecham Pharmaceuticals, Collegeville, PA; and
Zeneca Pharmaceuticals, Macclesfield, England and Wilmington, DE. Every
effort will be made to select an internship environment which will complement
the trainee's research interests and his/her career goals and objectives.
BIOTECHNOLOGY SEMINAR SERIES
To ensure communication between the trainees and the trainers in The
University of Kansas Biotechnology Predoctoral Training Program and exposure of
this training program to the external scientific community, the Steering
Committee sponsors and coordinates a monthly seminar series entitled,
"Pharmaceutical Aspects of Biotechnology." Participation is
open to the public and presentations will be given by faculty and students at
The University of Kansas and by external industrial and academic scientists
involved in biotechnology research related to the objectives of this training
program.
RESEARCH COMPONENT
Trainees in this program are selected based in part on the relevance of
their Ph.D. dissertation research to the objectives of this training
program. The research of all of the trainees is of a basic nature and
focuses on problems relevant to the analysis, delivery and formulation of
materials (e.g., peptides, proteins, nucleic acids) arising from
biotechnology. By focusing on basic research projects, the trainees
learn: (1) how to ask important, concept-oriented questions; (2) how to design
appropriate experiments to test the concepts and control for artifacts; and (3)
how to analyze the resulting data. The trainees are exposed to more
applied research problems related to the analysis, delivery, and formulation of
biotechnology products through their industrial internship. Examples of
dissertation projects are provided in Table 2 below.
FACILITIES
The University of Kansas research laboratories are equipped with
state-of-the-art instrumentation. Equipment is available to support all
aspects fo chemical, biochemical, engineering or computational research.
Specialized laboratories available to faculty and students include: The Nuclear
Magnetic Resonance Laboratory; The Mass Spectrometry Laboratory; The Molecular
Modeling Research and Molecular Graphics and Modeling Laboratories; The
Electron Microscopy Laboratory; The X-Ray Crystallographic Laboratory; The
Instrumentation Design Laboratory; and The Biochemical Research Service
Laboratories.
|
Mentor |
Collaborator(s) |
Type of Project |
Title |
|
Jeffrey Aube |
Ronald T. Borchardt |
Delivery |
Absorption Properties of Peptide Peptidomimetics |
|
Kenneth L. Audus |
John F. Stobaugh |
Delivery |
Carrier-Mediated Peptide Transport by Brain Microvessel Endothelium |
|
Ronald T. Borchardt |
Jeffrey Aube |
Delivery |
Transport Characteristics of Peptide Mimetics |
|
Ronald T. Borchardt |
Teruna J. Siahaan |
Delivery |
Cyclic Prodrugs of Opioid Peptides |
|
Robert C. Dunn |
None |
Delivery |
Development of Near-Field Fiber Optic |
|
Krzysztof Kuczera |
Richard L. Schowen |
Formulation |
Molecular Modeling of Protein Degradation |
|
Brian B. Laird |
Walter Kob (Univ. of Mainz, Germany) |
Formulation |
Localization in Glasses and Supercooled Liquids: Theory and Computer Simulation |
|
Cynthia K. Larive |
None |
Analytical |
Development of NMR Methods for the Analysis of Self-Aggregation Equilibria of Peptides and Proteins |
|
Craig E. Lunte |
Susan M. Lunte |
Analytical |
Sampling and Detection of Pharmacologically and Biochemically Active Peptides |
|
Susan M. Lunte |
Bret Berner (Cygnus Pharmaceuticals) |
Analytical |
Glycoprotein Characterization by Capillary Electrophoresis with Electrochemical Detection |
|
Susan M. Lunte |
Kenneth L. Audus |
Analytical |
Microanalytical Methods for the Study of the Transport and Metabolism of PeptidesAcross the Blood-Brain Barrier |
|
C. Russell Middaugh |
Thomas C. Squier |
Delivery |
Phospholamban Structure and Function |
|
C. Russell Middaugh |
D. Volkin (Merck) |
Delivery |
Atypical Protein Membrane Transport |
|
C. Russell Middaugh |
R. Pearlman (Megabios) |
Delivery |
Construction of Nonviral Gene Delivery Vectors |
|
C. Russell Middaugh |
None |
Delivery |
Mechanism of the Membrane Transport of Plasmid and Plasmid Complexes |
|
C. Russell Middaugh |
None |
Analytical |
Analysis of Plasmid-Based Pharmaceuticals |
|
Mark L.Richter |
Richard L. Schowen |
Formulation |
Refolding of ATP Synthase Subunits from E. coli Inclusion Bodies |
|
Christian Schoneich |
George S. Wilson |
Formulation |
Mechanisms of Protein and Peptide Oxidation by Reactive Oxygen Species |
|
Richard L. Schowen |
Ronald T. Borchardt |
Formulation |
Kinetics adn Mechanisms of Hydrolysis of a Hexapeptide-DerivedCyclic Imide in Polymer Matrices |
|
Richard L. Schowen |
Ronald T. Borchardt |
Formulation |
Formation and Decomposition of Cyclic Intermediates in Peptide Deamidation |
|
Teruna J. Siahaan |
Kenneth L. Audus |
Delivery |
Modulation of Intercellular Junctions by HAV Peptides |
|
Teruna J. Siahaan |
Ronald T. Borchardt |
Delivery |
Improving Oral Bioavailability of RGD-Peptidomimetics |
|
Teruna J. Siahaan |
Paul Stoker |
Analysis/ |
Conformation and Stability Studies of Linear and Cyclic RGD-Peptides |
|
Teruna J. Siahaan |
Stephen H. Benedict |
Analysis/ |
Conformation, Stability and Mechanisms of Action of Immunosuppressive Peptides Derived from ICAM-1 and LFA-1 |
|
Marylee Z. Southard |
John Gauch |
Analytical |
Visualization of Cellular Stress Responses in Flow Culture |
|
Thomas C. Squier |
None |
Formulation |
Molecular Mechanisms Underlying Liposome Stability |
|
Thomas C. Squier |
Christian Schoneich |
Formulation |
Stability of Oxidatively Modified Proteins |
|
Thomas C. Squier |
None |
Formulation/ |
Changes in Protein Structure and Dynamics Induced by Oxidation of Methionine Sulfoxide as Examined by Fluorescence Spectroscopy |
|
Valentino J. Stella |
Elizabeth M. Topp |
Formulation/ |
Coupling of Immune Modulators and Anticancer Drugs to Hyaluronic Acid for Targeted Drug Delivery to the Lymphatics |
|
John F. Stobaugh |
Susan M. Lunte |
Analytical |
Developmentof Micro-Solid-Phase Derivatization Characteristics for the Analysis of Peptides |
|
Bala Subramaniam |
Valentino J. Stella |
Formuation |
Micronization of Biotechnology Products with Supercritical Carbon Dioxide |
|
Elizabeth M. Topp |
Ronald T. Borchardt |
Formulation |
Role of Mobility in the Polymer in Peptide Deamidation in Polymer Matrices |
|
Elizabeth M. Topp |
Ronald T. Borchardt |
Formulation |
Effect of Water/Polymer Interactions on Peptide Deamidation in Polymer Matrices |
|
George S. Wilson |
Todd Williams |
Analytical |
Conformational Recognition of Proteins by Immunoassay |
Updated 1/6/98.