Department of Pharmaceutical Chemistry
COURSE REQUIREMENTS FOR THE AREAS OF
SPECIALIZATION
Trainees are required to select an area of specialization (analytical,
formulation, delivery) and satisfy the course requirements listed below. The
courses required in each area of specialization provide the trainees with
exposure to the practical problems associated with formulation, delivery, and
analysis of drug candidates. Such information will be particularly
helpful to trainees from departments other than pharmaceutical chemistry.
ANALYTICAL
Trainees selecting the analytical area of specialization are required to
successfully complete Pharmaceutical Chemistry 864, Pharmaceutical Analysis, and
Chemistry 959, Bioanalytical Chemistry.
- Pharmaceutical Chemistry
864 (PHCH 864): Pharmaceutical Analysis. This course emphasizes
separation technology used for the analysis of drugs in media such as: the
bulk drug substance, drug formulations, and biological fluids and
tissues. The following topics are discussed: theory of liquid
chromatography, applications of liquid chromatography, sample preparation,
method optimization, chromatography of peptides and proteins, and
derivatization techniques. Instructors: Professors J. Stobaugh
(Pharmaceutical Chemistry) and S. Lunte (Pharmaceutical Chemistry).
and
- Chemistry 959 (CHEM 959):
Bioanalytical Chemistry. This course emphasizes the biological
aspects of analytical chemistry including immunoassays, separations of
macromolecules, electrophoresis, radiochemical assays, electrochemical
assays, enzyme-based assays, biosensors, and spectroscopic techniques such
as NMR, CD, etc. Instructors: Professors G. Wilson (Chemistry,
Pharmaceutical Chemistry), C. Larive (Chemistry), C. Lunte (Pharmaceutical
Chemistry), T. Siahaan (Pharmaceutical Chemistry), and P. Gegenheimer
(Biochemistry, Cell & Molecular Biology).
DELIVERY
Trainees selecting the delivery area of specialization are required to
successfully complete Phannaceutical Chemistry 745, Advanced Drug Delivery, and
Pharmaceutical Chemistry 976, Advanced Topics in Biopharmaceutics and
Pharmacokinetics.
- Pharmaceutical Chemistry
745 (PHCH 745): Advanced Drug Delivery. This course provides
trainees with an overview of modem strategies of drug delivery.
Topics which are discussed include: biological barriers to drug delivery;
macromolecules as drug carriers; small molecules as drug carriers; cells
as drug delivery systems; microparticulate drug carriers; and
pharmacokinetics and pharmacodynamic considerations in directed drug
delivery. Instructors: Professor K.L. Audus (Pharmaceutical
Chemistry), R.T. Borchardt (Pharmaceutical Chemistry), V.J. Stella
(Pharmaceutical Chemistry) and invited speakers.
and
- Pharmaceutical Chemistry
976 (PHCH 976): Advanced Topics in Biopharmaceutics and Pharmacokinetics.
This course provides trainees with exposure to the quantitative treatment
of the processes involved with drug absorption, distribution, metabolism
and excretion in living systems. Topics covered in this course
include: classical pharmacokinetics; non-linear pharmacokinetics; advanced
concepts in pharmacokinetic modeling; biological barriers to efficient
drug delivery; and pharmacokinetics in dosage form development.
Instructors: Professors E.M. Topp (Pharmaceutical Chemistry), V.J. Stella
(Pharmaceutical Chemistry), K.L. Audus (Pharmaceutical Chemistry and
Pharmacology and Toxicology) and R.T. Borchardt (Pharmaceutical Chemistry
and Biochemistry).
FORMULATION
Trainees selecting the formulation area of specialization are required to
successfully complete Pharmaceutical Chemistry 862, Pharmaceutical Equilibria, and
Pharmaceutical Chemistry 972, Mechanisms of Drug Deterioration and
Stabilization.
- Pharmaceutical Chemistry
862 (PHCH 862): Pharmaceutical Equilibria. The objective of this
course are to apply basic thermodynamic principles to systems of interest
to pharmaceutical scientists. Physical properties of ideal and
nonideal solutions are discussed including methods for determining and
predicting solubility and ionization phenomena. The thermodynamics
of ligand binding interactions are developed with special attention to
small molecule-protein binding equilibria. Instructors: Professors
J.H. Rytting (Pharmaceutical Chemistry), C. Schoneich (Pharmaceutical
Chemistry), and C. Russell Middaugh (Pharmaceutical Chemistry).
and
- Pharmaceutical Chemistry
972 (PHCH 972): Mechanisms of Drug Deterioration and Stabilization.
The objective of the course is to enable students to recognize from the
chemical structure of drug molecules including peptides and proteins,
which compounds are likely to present stability problems under a variety
of conditions. 'Me course presents students with the principles
necessary to carry out stability evaluations of drugs and the quantitative
interpretation of the accumulated data from a thorough study.
Particular emphasis is placed on how these degradative processes can be
prevented or reduced to allow the formulation of these drugs for
therapeutic use. Instructors: Professors V.J. Stella (Pharmaceutical
Chemistry), R.T. Borchardt (Pharmaceutical Chemistry), R.L. Schowen
(Pharmaceutical Chemistry, Chemistry and Biochemistry, Cell &
Molecular Biology), T. Siahaan (Pharmaceutical Chemistry) and C. Schoneich
(Pharmaceutical Chemistry).
Updated 1/6/98.