Department of Pharmaceutical Chemistry
TRAINING PROGRAM
COURSE REQUIREMENTS FOR THE AREAS OF
SPECIALIZATION
Students participating in this predoctoral training program are required
to satisfy their home department's course requirements for a Ph.D. degree, as
well as the training program's requirements that are outlined in Figure 1
below. The training program's requirements include core courses for all
students and courses required for a student's areas of specialization (e.g.,
analytical, delivery, or formulation).
CORE COURSE REQUIREMENTS
All students in The University of Kansas Biotechnology Predoctoral Training
Program are required to successfully complete Biology 718, Laboratory in
Molecular Biology, Pharmaceutical Chemistry 870, Advanced Pharmaceutical
Biotechnology, and Pharmaceutical Chemistry 801, Issues in Scientific
Integrity. These core requirements expose all of the students to the
principles of molecular biology, pharmaceutical biotechnology and scientific
ethics, the areas essential for them to conduct research and development on
biotechnology products.
- Biology 718 (BIOL 718):
Laboratory in Molecular Biology. This coures provides the
trainees with didactic and laboratory training in recombinant DNA
technology and molecular cloning. Instructor: Professor D.A. Stetler
(Biochemistry, Cell & Molecular Biology).
and
- Pharmaceutical Chemistry
870 (PHCH 870): Advanced Pharmaceutical Biotechnology. The
objective of this course is to introduce the students to the discovery,
development and production of pharmaceutical proteins. In the
discovery section, the role of structure in governing protein activity,
specificity and stability particularly for pharmaceutically important proteins
will be covered. Physical and spectroscopic methods for analysis of
protein structure will be described. Degradation processes, both
chemical and physical, which are peculiar to proteins will be presented,
as well as strategies designed to prevent them. Introduction to
recombinant DNA technology, large scale production, purification, and
isolation procedures used for recombinant proteins in the pharmaceutical
industry wil be covered in the development and production sections.
Several new topics including oligonucleotides and combinatorial chemistry
will be added due to the recent increased attention on these topics.
Procedures for handling regulatory guidelines (filing NDA's and IND's)
will also be addressed. Instructors: Professor Teruna J. Siahaan
(Pharmaceutical Chemistry) and invited speakers.
and
- Pharmaceutical Chemistry
801 (PHCH 801, MDCM 801, CHEM 801, BIOL 801): Issues in Scientific
Integrity. Lectures and discussion on ethical issues in
the conduct of a scientific career, with emphasis on practical topics of
special importance in molecular-level research in the chemical, biological
and pharmaceutical sciences. Topics will include the nature of
ethics, the scientist in the laboratory, the scientist as an author,
grantee, reviewer, employer/employee, teacher/student, and
citizen. Instructors: Professors R.L. Schowen (Pharmaceutical
Chemistry, Chemistry, Biochemistry, Cell & Molecular Biology) and J.H.
Rytting (Pharmaceutical Chemistry) and invited speakers.
Figure 1. Course Requirements
for Trainees Participating in The University of Kansas Biotechnology
Predoctoral Training Program
|
Department's Requirements for the Ph.D. Degree
|
|
Core Courses for Biotechnology Training Program
- BIOL 718,
Laboratory in Molecular Biology
and
- PHCH 870, Advanced
Pharmaceutical Biotechnology
and
- PHCH 801, Issues
in Scientific Integrity
|
The student
can choose to specialize in one of these three areas:
|
Analytical Area of Specialization
- PHCH 864,
Pharmaceutical Analysis
and
- PHCH 959,
Bioanalytical Chemistry
|
Delivery Area of Specialization
- PHCH 745, Advanced
Drug Delivery
and
- PHCH 976, Advanced
Topics in Biopharmaceutics and Pharmacokinetics
|
Formulation Area of Specialization
- PHCH 862,
Pharmaceutical Equilibria
and
- PHCH 972,
Mechanisms of Deterioration and Stabilization
|
Updated 1/6/98.